Last updated: 2021-03-24
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Knit directory: toxin_dose_responses/
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Modified: analysis/doseresponsemodels.Rmd
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| File | Version | Author | Date | Message |
|---|---|---|---|---|
| Rmd | b5eaca5 | sam-widmayer | 2021-03-24 | NIEHS index update |
| html | 368d427 | sam-widmayer | 2021-03-24 | Build site. |
| Rmd | 4e761c3 | sam-widmayer | 2021-03-24 | wflow_git_commit(“analysis/index.Rmd”, message = ) |
| html | a18d5ac | sam-widmayer | 2021-03-08 | Build site. |
| html | 353bc55 | sam-widmayer | 2021-03-08 | Build site. |
| Rmd | fe46dd3 | sam-widmayer | 2021-03-08 | temporarily hide PD1074 preliminary data |
| Rmd | 94bdf85 | sam-widmayer | 2021-03-08 | fix analysis list |
| html | cb6e132 | sam-widmayer | 2021-03-06 | Build site. |
| Rmd | 0c9d312 | sam-widmayer | 2021-03-05 | initiate toxin DRC analysis repo |
| Rmd | e1f14ae | sam-widmayer | 2021-03-05 | Start workflowr project. |
This research is part of a three-lab collaboration to understand the genetic basis of natural variation in C. elegans xenobiotic responses. The following analyses have been conducted jointly by Tim Crombie and Sam Widmayer.
An overview of 8 strain dose-response curves. We exposed C. elegans strains with diverse genetic makeups to a suite of toxicants with differing modes of action. There were a variety of responses and, importantly, we observed that strains varied in their susceptibility to each toxicants. We report EC50 estimates for each compound where models could be inferred, and provide brief overviews of data quality for assays conducted using each compound.
Heritability describes the variance in a phenotype (in our case, toxicant susceptibility) that can be ascribed to genetic differences between strains. We report estimates of heritability in the broad-sense (variance attributable to genetic background differences) and the narrow-sense (variance attributable to the additive effects of segregating alleles). Each dot in broad-sense heritability plots reflect an individual estimate of heritability wherein phenotype replicates for a given dose, regardless of strain, were sampled with replacement.