Publications

Variation in anthelmintic responses are driven by genetic differences among diverse C. elegans wild strains
Shaver AO Wit J Dilks CM Crombie TA Li H Aroian RV Andersen EC
(2023 March 8) PLoS Pathogens [ DOI ]

Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum from domestic dogs throughout the USA and discovery of a novel β-tubulin benzimidazole resistance mutation
Venkatesan A Jimenez Castro PD Morosetti A Horvath H Chen R Redman E Dunn K Collins JB Fraser JS Andersen EC Kaplan RM Gilleard JS
(2023 March 2) PLoS Pathogens [ DOI ]

The turkey ascarid, Ascaridia dissimilis, as a model genetic system
Collins JB Andersen EC
(2022 December 19) International Journal for Parasitology [ DOI ]

Natural genetic variation in the pheromone production of Caenorhabditis elegans
Lee D Fox BW Palomino DCF Panda O Tenjo FJ Koury EJ Evans KS Stevens L Rodrigues PR Kolodziej AR Schroeder FC Andersen EC
(2022 November 23) bioRxiv [ DOI ]

Different structural variant prediction tools yield considerably different results in Caenorhabditis elegans
Lesack K Mariene GM Andersen EC Wasmuth JD
(2022 November 19) PLoS ONE [ DOI ]

An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics
Shaver AO Garcia BM Gouveia GJ Morse AM Liu Z Asef CK Borges RM Leach FE Andersen EC Amster J Fendandez FM Edison AS McIntyre LM
(2022 November 14) Frontiers in Molecular Biosciences [ DOI ]

Characterization of larval growth in C. elegans cuticle mutants
Nyaanga J Shirman S Mangan NM Andersen EC
(2022 November 4) microPublication [ DOI ]

Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin
Gibson S Ness-Cohn E Andersen EC
(2022 October 16) International Journal for Parasitology, Drugs and Drug Resistance [ DOI ]

Genome-wide regulatory effects of STRs stabilized by elevated expression of antioxidant genes in C. elegans
Zhang G Andersen EC
(2022 September 27) bioRxiv [ DOI ]

Natural variation in C. elegans short tandem repeats
Zhang G Wang Y Andersen EC
(2022 September 20) Genome Research [ DOI ]

C. elegans toxicant responses vary among genetically diverse individuals
Widmayer SJ Crombie TA Nyaanga JN Evans KS Andersen EC
(2022 August 16) Toxicology [ DOI ]

Linkage mapping reveals loci that underlie differences in C. elegans growth
Nyaanga J Andersen EC
(2022 August 4) G3 [ DOI ]

C. elegans as a model for inter-individual variation in metabolism
Fox BW Ponomarova O Lee YU Zhang G Glese GE Walker M Roberto NM Na H Rodrigues PR Curtis BJ Kolodziej AR Crombie TA Zdraljevic S Yilmaz LS Andersen EC Schroeder FS Walhout AJM
(2022 July 6) Nature [ DOI ]

Natural variation in the irld gene family affects insulin IGF signaling and starvation resistance
Webster AK Chitrakar R Powell M Chen J Fisher K Tanny RE Stevens L Evans KS Antoshechkin I Andersen EC Baugh LR
(2022 June 22) eLife [ DOI ]

The impact of species-wide gene expression variation on Caenorhabditis elegans complex traits
Zhang G Roberto NM Lee D Hahnel SR Andersen EC
(2022 June 16) Nature Communications [ DOI ]

Interactions of C. elegans beta-tubulins with microtubule inhibitor albendazole
Pallotto LM Dilks CM Park YJ Smit RB Lu B Gopalakrishnan C Gilleard JS Andersen EC Mains PE
(2022 June 8) Genetics [ DOI ]

An automated approach to quantify chemotaxis index in Caenorhabditis nematodes
Crombie TA Chikuturudzi C Cook DE Andersen EC
(2022 May 24) microPublication [ DOI ]

Evaluating the power and limitations of genome-wide association mapping in Caenorhabditis elegans
Widmayer SJ Evans KS Zdraljevic S Andersen EC
(2022 May 4) G3 [ DOI ]

Changes in body shape implicate cuticle stretch in C. elegans growth control
Nyaanga J Goss C Zhang G Ahmed HN Andersen EJ Miller IR Rozenich JK Swarthout IL Vaughn JA Mangan NM Shirman S Andersen EC
(2022 April 13) Cells and Development [ DOI ]

Genomic signatures of selection associated with benzimidazole drug treatments in Haemonchus contortus field populations
Wit J Workentine ML Redman E Laing R Stevens L Cotton JA Chaudry U Ali Q Andersen EC Yeaman S Wasmuth JD Gilleard JS
(2022 September 13) International Journal for Parasitology Drugs and Drug Resistance [ DOI ]

Chromosome-level reference genomes for two strains of Caenorhabditis briggsae, an improved platform for comparative genomics
Stevens L Moya ND Tanny RE Gibson SB Tracey A Na H Zhan Y Chitrakar R Dekker J Walhout AJM Baugh LR Andersen EC
(2022 March 28) Genome Biology and Evolution [ DOI ]

A highly scalable approach to perform ecological surveys of selfing Caenorhabditis nematodes
Crombie TA Tanny RE Buchanan CM Andersen EC
(2022 March 3) JoVE [ DOI ]

Megapixel camera arrays for high-resolution animal tracking in multiwell plates
Barlow I Feriani L Minga E McDermott-Rouse A O'Brien T Liu Z Hofbauer M Stowers JR Andersen EC Ding SS Brown AEX
(2022 March 1) Communications Biology [ DOI ]

Local adaptation and spatiotemporal patterns of genetic diversity revealed by repeated sampling of Caenorhabditis elegans across the Hawaiian Islands
Crombie TA Battlay P Tanny RE Evans KS Buchanan CM Cook DE Dilks CM Stinson LA Zdraljevic S Zhang G Roberto NM Lee D Ailion M Hodgins KA Andersen EC
(2022 February 4) Molecular Ecology [ DOI ]

Natural genetic variation as a tool for discovery in Caenorhabditis nematodes
Andersen EC Rockman MV
(2022 January 4) Genetics [ DOI ]

High-throughput imaging of Caenorhabditis elegans aging using collective activity monitoring
Fouad AD Churgin MA Hayden J Xu J Park JI Liu A Teng C Sun H Parrado M Bowlin P La Torre MD Crombie TA Sedore CA Coleman-Hulbert AL Johnson E Phillips P Andersen EC Fang-Yen C
(2021 October 19) bioRxiv [ DOI ]

The distribution of mutational effects on fitness in Caenorhabditis elegans inferred from standing genetic variation
Gilbert KJ Zdraljevic S Cook DE Cutter AD Andersen EC Baer CF
(2021 September 26) Genetics [ DOI ]

easyFulcrum, An R package to process and analyze ecological sampling data generated using the Fulcrum mobile application
Di Bernardo M Crombie TA Cook DE Andersen EC
(2021 September 22) PLoS ONE [ DOI ]

Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles
Dilks CM Koury EJ Buchanan CM Andersen EC
(2021 September 7) International Journal for Parasitology Drugs and Drug Resistance [ DOI ]

easyXpress, An R package to analyze and visualize high-throughput C. elegans microscopy data generated using CellProfiler
Nyaanga J Crombie TA Widmayer SJ Andersen EC
(2021 August 13) PLoS ONE [ DOI ]

From QTL to gene, Caenorhabditis elegans facilitates discoveries of the genetic mechanisms underlying natural variation
Evans KS van Wijk MH McGrath PT Andersen EC Sterken MG
(2021 July 3) Trends in Genetics [ DOI ]

The Caenorhabditis elegans and Haemonchus contortus beta-tubulin genes cannot substitute for loss of the Saccharomyces cerevisiae beta-tubulin gene
Gibson SB Harper CS Lackner LL Andersen EC
(2021 June 29) microPublication [ DOI ]

Mutability of mononucleotide repeats, not oxidative stress, explains the discrepancy between laboratory-accumulated mutations and the natural allele-frequency spectrum in C. elegans
Rajaei M Saxena AS Johnson LM Snyder MC Crombie TA Tanny RE Andersen EC Joyner-Matos J Baer CF
(2021 June 23) Genome Research [ DOI ]

Two novel loci underlie differences in Caenorhabditis elegans abamectin responses
Evans KS Wit J Stevens L Hahnel SR Rodriguez B Park G Zamanian M Brady SC Chao E Introcaso K Tanny RE Andersen EC
(2021 March 2) PLoS Pathogens [ DOI ]

Long-term metabolomics reference material
Gouveia GJ Shaver AO Garcia BM Morse AM Rodriguez B Park G Andersen EC Edison AS McIntyre LM
(2021 June 2) ACS Analytical Chemistry [ DOI ]

Balancing selection maintains ancient genetic diversity in Caenorhabditis elegans
Lee D Zdraljevic S Stevens L Wang Y Tanny RE Crombie TA Cook DE Webster AK Chirakar R Baugh LR Sterken MG Braendle C Felix MA Rockman MV Andersen EC
(2021 February 23) Nature Ecology and Evolution [ DOI ]

Natural variation in fertility is correlated with species-wide levels of divergence in Caenorhabditis elegans
Zhang G Mostad JD Andersen EC
(2021 May 1) G3 [ DOI ]

Xenobiotic metabolism and transport in Caenorhabditis elegans
Hartman JH Widmayer SJ Bergemann CM King DE Morton KS Romersi RS Jameson LE Leung MCK Andersen EC Taubert S Meyer JN
(2021 February 22) Journal of Toxicology and Environmental Health, Part B [ DOI ]

Natural variation in Caenorhabditis elegans responses to the anthelmintic emodepside
Wit J Andersen EC
(2021 April 6) International Journal for Parasitology Drugs and Drug Resistance [ DOI ]

Selfing is the safest sex for Caenorhabditis tropicalis
Noble LM Yuen J Stevens L Moya N Persaud R Moscatelli M Jackson J Zhang G Chitrakar R Baugh LR Braendle C Andersen EC Seidel HS Rockman MV
(2021 January 11) eLife [ DOI ]

Complementary Approaches to Understand Anthelmintic Resistance Using Free-Living and Parasitic Nematodes
Wit J Dilks C Andersen EC
(2020 December 13) Trends in Parasitology [ DOI ]

Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans
Evans KS Zdraljevic S Stevens L Collins K Tanny RE Andersen EC
(2020 November 11) PLoS Genetics [ DOI ]

Caenorhabditis elegans in anthelmintic research - Old model, new perspectives
Hahnel SR Dilks CM Heisler I Andersen EC Kulke D
(2020 September 26) International Journal for Parasitology Drugs and Drug Resistance [ DOI ]

The cadmium-responsive gene, cdr-6, does not influence Caenorhabditis elegans responses to exogenous zinc
Evans KS Andersen EC
(2020 September 5) microPublication [ DOI ]

Culture and assay of large-scale mixed-stage Caenorhabditis elegans populations
Shaver AO Gouveia GJ Kirby PS Andersen EC Edison AS
(2020 August 26) Journal of Visualized Experiments [ DOI ]

Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles
Dilks CM Hahnel SR Sheng Q Long L McGrath PT Andersen EC
(2020 August 5) International Journal for Parasitology Drugs and Drug Resistance [ DOI ]

Natural variation in a glucuronosyltransferase modulates propionate sensitivity in a C. elegans propionic acidemia model
Na H Zdraljevic S Tanny RE Walhout AJM Andersen EC
(2020 July 3) PLoS Genetics [ DOI ]

The gene scb-1 underlies variation Caenorhabditis elegans chemotherapeutic responses
Evans KS Andersen EC
(2020 May 8) G3 [ DOI | Pubmed ]

The nematode Caenorhabditis elegans nematodes and the terrestrial isopod Porcellio scaber likely interact opportunistically
Archer H Deiparine S Andersen EC
(2020 June 26) PLoS ONE [ DOI | Pubmed ]

A spontaneous complex structural variant in rcan-1 increases exploratory behavior and laboratory fitness of Caenorhabditis elegans
Zhao Y Long L Wan J Biliya S Brady SC Lee D Ojemakinde A Andersen EC Vannberg FO Lu H McGrath PT
(2020 February 24) PLoS Genetics [ DOI | Pubmed ]

Effects of telomerase overexpression in the model organism Caenorhabditis elegans
Bayat M Tanny RE Wang Y Herden C Daniel J Andersen EC Liebau E Waschk DEJ
(2020 January 16) Gene [ DOI | Pubmed ]

Selection and gene flow shape niche-associated variation of pheromone response
Lee D Zdraljevic S Frezal L Hsu J Sterken MG Riksen JAG Wang J Kammenga JE Braendle C Felix A Schroeder FC Andersen EC
(2019 March 26) Nature Ecology and Evolution [ DOI | Pubmed | PMC ]

The Caenorhabditis Genetics Center (CGC) and the Caenorhabditis elegans Natural Diversity Resource
Daul AL Andersen EC Rougvie AE
(2019 December 8) The Biological Resources of Model Organisms [ ]

An escape-room inspired game for genetics review
Brady SC Andersen EC
(2019 December 6) Journal of Biological Education [ DOI ]

Deep sampling of Hawaiian Caenorhabditis elegans reveals high genetic diversity and admixture with global populations
Crombie TA Zdraljevic S Cook DE Tanny RE Brady SC Wang Y Evans KS Hahnel S Lee D Rodriguez BC Zhang G van der Zwaag J Kiontke KC Andersen EC
(2019 November 6) eLife [ DOI | Pubmed | PMC ]

Population selection and sequencing of Caenorhabditis elegans wild isolates identifies a region on chromosome III affecting starvation resistance
Webster AK Hung A Moore BT Guzman R Jordan JM Kaplan REW Hibshman JD Tanny RE Cook DE Andersen EC Baugh LR
(2019 September 6) G3 [ DOI | Pubmed | PMC ]

Long-read sequencing reveals intra-species tolerance of substantial structural variations and new subtelomere formation in C. elegans
Kim C Kim J Kim S Cook DE Evans KS Andersen EC Lee J
(2019 May 23) Genome Research [ DOI | Pubmed ]

Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism
Zdraljevic S Fox BW Strand C Panda O Tenjo FJ Brady SC Crombie TA Doench JG Schroeder FC Andersen EC
(2019 Apr 08) eLife [ DOI | Pubmed | PMC ]

A novel gene underlies bleomycin-response variation in Caenorhabditis elegans
Brady SC Zdraljevic S Bisaga KW Tanny RE Cook DE Lee D Wang Y Andersen EC
(2019 May 30) Genetics [ DOI | Pubmed ]

Evolution of sperm competition - Natural variation and genetic determinants of Caenorhabditis elegans sperm size
Gimond C Vielle A Soares NS Zdraljevic S McGrath P Andersen EC Braendle C
(2018 Dec 19) Genetics [ DOI | Pubmed | PMC ]

Tightly linked antagonistic-effect loci underlie polygenic demographic variation in C. elegans
Bernstein MR Zdraljevic S Andersen EC Rockman MV
(2018 Sep 27) Evolution Letters [ DOI | Pubmed | PMC ]

Extreme allelic heterogeneity at a Caenorhabditis elegans beta-tubulin locus explains natural resistance to benzimidazoles
Hahnel SR Zdraljevic S Rodriguez BC Zhao Y McGrath PT Andersen EC
(2018 Oct 29) PLOS Pathogens [ DOI | Pubmed | PMC ]

Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses
Evans KS Brady SC Bloom JS Tanny RE Cook DE Giuliani SE Hippleheuser SW Zamanian M Andersen EC
(2018 Oct 19) Genetics [ DOI | Pubmed | PMC ]

Discovery of genomic intervals that underlie nematode responses to benzimidazoles
Zamanian M Cook DE Zdraljevic S Brady SC Lee D Lee J Andersen EC
(2018 Mar 5) PLoS Negl Trop Dis [ DOI | Pubmed ]

Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms
Zdraljevic S Andersen EC
(2017 Sept 09) Curr. Opin. Genet. Dev. [ DOI | Pubmed ]

The genetic basis of natural variation in a phoretic behavior
Lee D Yang H Kim J Brady S Zdraljevic S Zamanian M Kim H Paik YK Kruglyak L Andersen EC Lee J
(2017 Aug 17) Nat Commun [ DOI | Pubmed | PMC ]

Natural variation in a single amino acid underlies physiological responses to topoisomerase II poisons
Zdraljevic S Strand C Seidel HS Cook DE Doench JG Andersen EC
(2017 Apr 07) PLOS Genetics [ DOI | Pubmed | Data ]

VCF-kit - Assorted utilities for the variant call format
Cook DE Andersen EC
(2017 Jan 16) Bioinformatics [ DOI | Pubmed ]

Natural variation in the distribution and abundance of transposable elements across the Caenorhabditis elegans species
Laricchia KM Zdraljevic S Cook DE Andersen EC
(2017 May 09) Molecular Biology and Evolution [ DOI | Pubmed | Data ]

Copper Oxide Nanoparticles Impact Several Toxicological Endpoints and Cause Neurodegeneration in Caenorhabditis elegans
Mashock MJ Zanon T Kappell AD Petrella LN Andersen EC Hristova KR
(2016 Dec 2) PLoS ONE [ DOI | Pubmed ]

Correlations of geneotype with climate parameters suggest Caenorhabditis elegans niche adaptations
Evans KS Zhao Y Brady SC Long L McGrath PT Andersen EC
(2016 Nov 18) G3 [ DOI | Pubmed | Data ]

CeNDR, the Caenorhabditis elegans natural diversity resource
Cook DE Zdraljevic S Roberts JP Andersen EC
(2016 Oct 3) Nucleic Acids Research [ DOI | Pubmed ]

The genetic basis of natural variation in C. elegans telomere length
Cook DE Zdraljevic S Tanny RE Seo B Riccardi DD Noble LM Rockman MV Alkema MJ Braendle C Kammenga JE Wang J Kruglyak L Félix MA Lee J Andersen EC
(2016 Sep 1) Genetics [ DOI | Pubmed | Data ]

Mutation Is a Sufficient and Robust Predictor of Genetic Variation for Mitotic Spindle Traits in Caenorhabditis elegans
Farhadifar R Ponciano JM Andersen EC Needleman DJ Baer CF
(2016 Aug 1) Genetics [ DOI | Pubmed | PMC ]

Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans
Large EE Xu W Zhao Y Brady SC Long L Butcher RA Andersen EC McGrath PT
(2016 July 28) PLoS Genet. [ DOI | Pubmed ]

Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases
Zamanian M Andersen EC
(2016 July 11) FEBS Journal [ DOI | Pubmed ]

Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856
Thompson OA Snoek LB Nijveen H Sterken MG Volkers RJM Brenchley R van 't Hof A Bevers RPJ Cossins AR Yanai I Hajnal A Schmid T Perkins JD Spencer D Kruglyak L Andersen EC Moerman DG Hillier LW Kammenga JE Waterston RH
(2015 May 19) Genetics [ DOI | Pubmed ]

The laboratory domestication of Caenorhabditis elegans
Sterken MG Snoek LB Kammenga JE Andersen EC
(2015 Mar 21) Trends in Genetics [ DOI | Pubmed ]

A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains
Andersen EC Shimko TC Crissman JR Ghosh R Bloom JS Seidel HS Gerke JP Kruglyak L
(2015 Mar 13) G3 (Bethesda) [ DOI | Pubmed | Data ]

Scaling, Selection, and Evolutionary Dynamics of the Mitotic Spindle
Farhadifar R Baer CF Valfort AC Andersen EC Muller-Reichert T Delattre M Needleman DJ
(2015 Feb 11) Current Biology [ DOI | Pubmed ]

The red death meets the abdominal bristle - Polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans.'
Etienne V Andersen EC Ponciano JM Blanton D Cadavid A Joyner-Matos J Matsuba C Tabman B Baer CF
(2015 Feb) Evolution [ DOI | Pubmed | PMC ]

A wild C. elegans strain has enhanced epithelial immunity to a natural microsporidian parasite.
Balla KM Andersen EC Kruglyak L Troemel ER
(2015 Feb) PLoS Pathogens [ DOI | Pubmed | PMC ]

COPASutils - An R Package for Reading, Processing, and Visualizing Data from COPAS Large-Particle Flow Cytometers
Shimko TC Andersen EC
(2014 Oct 20) PLoS One [ DOI | Pubmed | PMC ]

A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology
Andersen EC Bloom JS Gerke JP Kruglyak L
(2014 Feb) PLoS Genetics [ DOI | Pubmed | PMC ]

Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest
Felix MA Jovelin R Ferrari C Han S Cho YR Andersen EC Cutter AD Braendle C
(2013 Jan 12) BMC Evolutionary Biology [ DOI | Pubmed | PMC ]

Natural variation in a chloride channel subunit confers avermectin resistance in C. elegans
Ghosh R Andersen EC Shapiro JA Gerke JP Kruglyak L
(2012 Feb 3) Science [ DOI | Pubmed | PMC ]

Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
Andersen EC Gerke JP Shapiro JA Crissman JR Ghosh R Bloom JS Felix MA Kruglyak L
(2012 Mar) Nature Genetics [ DOI | Pubmed | PMC | Data ]

PCR-directed in vivo plasmid construction using homologous recombination in bakers yeast
Andersen EC
(2011 Jul 08) Methods in Molecular Biology [ DOI | Pubmed ]

Differential localization and independent acquisition of the H3K9me2 and H3K9me3 chromatin modifications in the Caenorhabditis elegans adult germ line.
Bessler JB Andersen EC Villeneuve AM
(2010 Jan) PLoS Genetics [ DOI | Pubmed | PMC ]

Variability in gene expression underlies incomplete penetrance
Raj A Rifkin SA Andersen EC van Oudenaarden A
(2010 Feb 18) Nature [ DOI | Pubmed | PMC ]

A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans
Reddy KC Andersen EC Kruglyak L Kim DH
(2009 Jan 16) Science [ DOI | Pubmed | PMC ]

Multiple levels of redundant processes inhibit Caenorhabditis elegans vulval cell fates
Andersen EC Saffer AM Horvitz HR
(2008 Aug) Genetics [ DOI | Pubmed | PMC ]

Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development
Andersen EC Horvitz HR
(2007 Aug) Development [ DOI | Pubmed ]

DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans
Reddien PW Andersen EC Huang MC Horvitz HR
(2007 Apr) Genetics [ DOI | Pubmed | PMC ]

C. elegans ISWI and NURF301 antagonize an Rb-like pathway in the determination of multiple cell fates
Andersen EC Lu X Horvitz HR
(2006 Jul) Development [ DOI | Pubmed ]

Patterns of gene expression during Drosophila mesoderm development
Furlong EE Andersen EC Null B White KP Scott MP
(2001 Aug 31) Science [ DOI | Pubmed ]